CMOS based high density micro array platform for electrochemical detection and enumeration of cells

Author

Chee Chung Wong ; Drews, Christoph ; Yu Chen ; Tze Sian Pui ; Arya, Sunil K. ; Weerasekera, Roshan ; Rahman, Abdur R. A.

Author_Institution

Inst. of Microelectron., A*STAR (Agency for Sci., Technol. & Res.), Singapore, Singapore

fYear

2013

fDate

9-11 Dec. 2013

Abstract

A highly sensitive label-free complementary-metal-oxide-semiconductor (CMOS) based high density micro-array for electrochemical detection and enumeration of breast tumor cell (MCF-7) is presented. The electrochemical impedance spectroscopy (EIS) based detection platform exhibited detection at single cell resolution (22 μm) and enumeration with mapping accuracy of ~80%. Maximum tumor-cell impedance increase of 28% was recorded.

Keywords

CMOS integrated circuits; biomedical electronics; electrochemical impedance spectroscopy; lab-on-a-chip; tumours; EIS-based detection platform; MCF-7; breast tumor cell enumeration; complementary-metal-oxide-semiconductor; electrochemical detection; electrochemical impedance spectroscopy; highly-sensitive label-free CMOS-based high-density microarray platform; mapping accuracy; single-cell resolution; tumor-cell impedance; Arrays; Gold; Immune system; Impedance; Impedance measurement; Microelectrodes;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices Meeting (IEDM), 2013 IEEE International

Conference_Location

Washington, DC

Type

conf

DOI

10.1109/IEDM.2013.6724628

Filename

6724628