Title :
CMOS based high density micro array platform for electrochemical detection and enumeration of cells
Author :
Chee Chung Wong ; Drews, Christoph ; Yu Chen ; Tze Sian Pui ; Arya, Sunil K. ; Weerasekera, Roshan ; Rahman, Abdur R. A.
Author_Institution :
Inst. of Microelectron., A*STAR (Agency for Sci., Technol. & Res.), Singapore, Singapore
Abstract :
A highly sensitive label-free complementary-metal-oxide-semiconductor (CMOS) based high density micro-array for electrochemical detection and enumeration of breast tumor cell (MCF-7) is presented. The electrochemical impedance spectroscopy (EIS) based detection platform exhibited detection at single cell resolution (22 μm) and enumeration with mapping accuracy of ~80%. Maximum tumor-cell impedance increase of 28% was recorded.
Keywords :
CMOS integrated circuits; biomedical electronics; electrochemical impedance spectroscopy; lab-on-a-chip; tumours; EIS-based detection platform; MCF-7; breast tumor cell enumeration; complementary-metal-oxide-semiconductor; electrochemical detection; electrochemical impedance spectroscopy; highly-sensitive label-free CMOS-based high-density microarray platform; mapping accuracy; single-cell resolution; tumor-cell impedance; Arrays; Gold; Immune system; Impedance; Impedance measurement; Microelectrodes;
Conference_Titel :
Electron Devices Meeting (IEDM), 2013 IEEE International
Conference_Location :
Washington, DC
DOI :
10.1109/IEDM.2013.6724628
