Application of Meta-level Abduction for the Treatment of Hypertension Using SOLAR

Hypertension is a multifactorial and multi-gene abnormality that affects 25 percent of the world´s population. Thus, in the last decades vast research has been conducted in order to determine the mechanisms of that disorder. This lead to the introduction of pathways that describe those mechanisms. Using that knowledge, scientists were able to design drugs that act directly on the pathway in order to reduce hypertension. The goal here is to establish a framework that enables us to rediscover those drugs using meta-level abduction. This can be done by using a combination of four pathways involved in the regulation of the blood pressure inside the body. In this context, causal rules are abduced to suppress vasoconstriction (vessel´s narrowing). We explore the difficulties we face with the contrast of an ideal framework and practical application, especially in the case of negative feedback loops and integrity constraints.