An In Vivo Study on the Oxidative Damage Induced by PBDE 209 on Liver Cells of Mice

To explore oxidative damage induced by PBDE 209 and its mechanism we carried out this research. Mice were given intragastrically with PBDE 209 via a metal gastric-tube at different levels (0, 50, 100, 200 mg/(kg·d)) for seven days and the malondialdehyde (MDA) content, superoxide dismutase (SOD) activities in liver and liver index were mensurated. Results showed that along with elevation of PBDE 209 concentration, SOD activities in mice decreased and 200 mg/(kg·d) PBDE 209 exposure group significantly decreased compared with control group (p <; 0.01). MDA content first aroused and then decreased. Further more, MDA content in all experimental groups was elevated compared with control group, and 50, 100 mg/(kg·d) PBDE 209 exposure group significantly increased (p <; 0.01). Liver index of all experimental groups was significantly higher than that of control group (p <; 0.01). These results indicate that PBED 209 can induce oxidative damage in liver of mice with apparent dose-dependent relationship.