Title :
Observations of Pathomorphology and Antioxidative Function of Brain Tissue in Chickens with Aluminum Exposure
Author :
Zhu Yan-zhu ; Li Yan-fei ; Gu Qing-Yun ; Liu Yun-Feng
Author_Institution :
Coll. of Veterinary Med., Northeast Agric. Univ., Harbin, China
Abstract :
The activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MAD) in cerebrum and cerebellum and pathomorphology of brain tissue were detected in chickens with different levels sub-chronic aluminum (Al) intoxication produced by continuous peritoneal injection of fixed volume and different gradient aluminum trichloride (AlCl3). The results showed that the activities of SOD in cerebrum and cerebellum were lower and the concentrations of MAD was higher in the experimental groups than in the control group (P<;0.05 or P<;0.01). There was dose-effect relationship between with AlCl3. Swell, atrophy, necrosis and karyopycnosis were observed in cerebrum centrum neurocytes and Purkinje´s cells of cerebellum by light microscope, which indicated that Al exposure damaged the brain tissue of chickens.
Keywords :
aluminium compounds; biological tissues; brain; cellular biophysics; chemical hazards; diseases; neurophysiology; toxicology; AlCl3; Purkinje´s cells; aluminum trichloride; antioxidative function; atrophy; brain tissue; cerebellum; cerebrum centrum neurocytes; dose-effect relationship; karyopycnosis; malondialdehyde; necrosis; pathomorphology; subchronic aluminum; superoxide dismutase; Aluminum; Animals; Atrophy; Biological materials; Brain; Educational institutions; Inorganic materials; Medical treatment; Microscopy; Nervous system;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5515231
