Title :
Multi-Objective Optimization Research for Effective Constituents of QiliQiangxin Capsule of Chinese Formula
Author :
Wang, Hongtao ; Jia, Jiming ; Tang, Siwen ; Xu, Dengfeng ; Zheng, Yajie ; Zhang, Huixin ; Wu, Yiling ; Liu, Renquan
Author_Institution :
Pharmacology Lab., Integration of Traditional & Western Med. Res. Acad. of Hebei Province, Shijiazhuang, China
Abstract :
The systematic effects from many active ingredients in Chinese medicine preparation are the highlight to evaluate curative effects and optimize the formula. The common design could get the ideal optimization. Qiliqiangxin(QLQX) capsule exerts its effects on chronic heart failure through cardiac and diuresis and dilating vessel. In our previous research 12 samples were obtained by water and alcohol extracting and macroporous resin purifying. The active sites were screened with the experiments of isolated frog heart and aorta perfusion and diuresis. The results suggested that W3, W4, E2, E3, E4 were major active sites. Here the LARS was adopted to design the experiment of heart failure in rats and optimize different index in the results. The study was to explore a novel method to optimize Chinese medicine formula.
Keywords :
cardiology; drugs; medicine; optimisation; porous materials; resins; Chinese medicine; Chinese medicine formula; QiliQiangxin capsule; chronic heart failure; curative effects; macroporous resin purification; multiobjective optimization research; systematic effects; Animals; Biological materials; Biomedical materials; Cardiac disease; Cardiovascular diseases; Design optimization; Heart; Materials testing; Medical tests; Rats;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5515683
