Title :
A Mathematical Model for Anti-HBV Infection Combination Therapy with Peginterferon Alfa-2a and Lamivudine
Author :
Zhang, Guo ; Zhao, Hong ; Xie, Qizhi
Author_Institution :
Grad. Sch., Tianjin Polytech. Univ., Tianjin, China
Abstract :
Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model consisting of two differential equation systems that enable us to describe and understand the dynamics of host cells, virus and the immune system. Our model provide a possible interpretation for the effect of combination therapy to the chronic HBV infection patients. In particularly, we can account for the phenomenon of HBV DNA load returned after stopping the therapy. Numerical simulations show that if we proceed with the treatment 6.8 years, the HBV virus will be completely eliminate in infected heptocytes.
Keywords :
DNA; cellular biophysics; differential equations; diseases; liver; microorganisms; molecular biophysics; patient treatment; physiological models; HBeAg-positive chronic hepatitis B patients; anti-HBV infection combination therapy; differential equation; heptocytes; lamivudine; peginterferon Alfa-2a; Biological system modeling; DNA; Differential equations; Drugs; Immune system; Liver diseases; Mathematical model; Medical treatment; Numerical simulation;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5515855
