Title :
A silicon-based ultrasonic immunoassay for detection of breast cancer antigens
Author :
Wang, Amy W. ; Kiwan, Radwan ; White, Richard M. ; Ceriani, Roberto L.
Author_Institution :
Berkeley Sensor & Acuator Center, California Univ., CA, USA
Abstract :
We report on a silicon-based immunosensor package that has direct application to the diagnostic detection of a breast cancer antigen in the sera of breast cancer patients. We couple the flexural plate wave (FPW) gravimetric sensor with a novel mass-amplifying label that increases sensor signal level (a shift of resonant frequency) from that of previous acoustic immunoassays, in which frequency shifts were due solely to the weight of the immunoglobulins. The use of a gravimetric immunoassay with a mass-amplifying label provides an alternative to radioimmunoassay, eliminating the need for radioactive labels that require costly disposal
Keywords :
biomedical equipment; biomedical ultrasonics; biosensors; elemental semiconductors; gravimeters; micromachining; packaging; patient diagnosis; proteins; silicon; ultrasonic transducers; 1.5 MHz; Si; Si-based ultrasonic immunoassay; breast cancer antigens detection; breast cancer patients; diagnostic detection; flexural plate wave gravimetric sensor; frequency shifts; immunosensor package; mass-amplifying label; sera; Acoustic sensors; Acoustic signal detection; Acoustic waves; Breast cancer; Cancer detection; Immune system; Proteins; Rough surfaces; Silicon; Surface roughness;
Conference_Titel :
Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-3829-4
DOI :
10.1109/SENSOR.1997.613615
