Bio-Behavioral Control, Glucose Variability, and Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes (T1DM)

Author

Breton, Marc D. ; Farhy, Leon S. ; Penberthy, Jennifer K. ; Kovatchev, Boris P.

Author_Institution

Sch. of Med., Virginia Univ., Charlottesville, VA

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

315

Lastpage

318

Abstract

In this paper we present a mathematical model and a computer simulation of the relationship between behavioral control of Type 1 diabetes (T1DM), blood glucose (BG) variability, and hypoglycemia-associated autonomic failure (HAAF). A stochastic behavioral self-control process was coupled with a dynamical system simulation of the dampening effect of counterregulation on BG oscillations. The resulting bio-behavioral control system was able to reproduce characteristics of hypoglycemic events in the field, such as temporal clustering of hypoglycemic episodes associated with HAAF, and occurrence of severe hypoglycemia as a result of periods of HAAF augmented by increased BG variability

Keywords

behavioural sciences; biocontrol; blood; diseases; medical computing; physiological models; stochastic processes; bio-behavioral control; blood glucose oscillations; blood glucose variability; computer simulation; counterregulation; dampening effect; dynamical system simulation; hypoglycemia-associated autonomic failure; hypoglycemic events; mathematical model; stochastic behavioral self-control process; temporal clustering; type 1 diabetes; Blood; Cities and towns; Control systems; Diabetes; Fluctuations; Insulin; Mathematical model; Physiology; Sugar; USA Councils;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260113

Filename

4461748