Title :
Induction of Osteoblast Differentiation Markers in Human Dermal Fibroblasts: Potential Application to Bone Tissue Engineering
Author :
Hee, Christopher K. ; Nicoll, Steven B.
Author_Institution :
Dept. of Bioeng., Pennsylvania Univ., Philadelphia, PA
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
Tissue engineered constructs have the potential to be used as replacements for current bone graft technologies. One component necessary for bone tissue engineering is a readily available, osteogenic cell source. Human dermal fibroblasts may have the potential to differentiate along an osteoblastic lineage, making them a candidate for use in bone tissue engineering applications. The objective of this study was to validate the ability of dermal fibroblasts to express gene and protein markers of osteoblastic differentiation and to explore their potential, in combination with biomaterial scaffolds and signaling factors, for use in bone tissue engineering
Keywords :
biochemistry; biomedical materials; bone; cellular biophysics; genetics; molecular biophysics; orthopaedics; skin; tissue engineering; biomaterial scaffolds; bone graft; bone tissue engineering; gene expression; human dermal fibroblasts; osteoblast differentiation markers; osteoblastic lineage; osteogenic cell source; protein markers; signaling factors; tissue engineered constructs; Biochemical analysis; Biochemistry; Bone tissue; Cells (biology); Cities and towns; Dermis; Fibroblasts; Gene expression; Humans; Pediatrics;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259308
