Induction of Osteoblast Differentiation Markers in Human Dermal Fibroblasts: Potential Application to Bone Tissue Engineering

Author

Hee, Christopher K. ; Nicoll, Steven B.

Author_Institution

Dept. of Bioeng., Pennsylvania Univ., Philadelphia, PA

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

521

Lastpage

524

Abstract

Tissue engineered constructs have the potential to be used as replacements for current bone graft technologies. One component necessary for bone tissue engineering is a readily available, osteogenic cell source. Human dermal fibroblasts may have the potential to differentiate along an osteoblastic lineage, making them a candidate for use in bone tissue engineering applications. The objective of this study was to validate the ability of dermal fibroblasts to express gene and protein markers of osteoblastic differentiation and to explore their potential, in combination with biomaterial scaffolds and signaling factors, for use in bone tissue engineering

Keywords

biochemistry; biomedical materials; bone; cellular biophysics; genetics; molecular biophysics; orthopaedics; skin; tissue engineering; biomaterial scaffolds; bone graft; bone tissue engineering; gene expression; human dermal fibroblasts; osteoblast differentiation markers; osteoblastic lineage; osteogenic cell source; protein markers; signaling factors; tissue engineered constructs; Biochemical analysis; Biochemistry; Bone tissue; Cells (biology); Cities and towns; Dermis; Fibroblasts; Gene expression; Humans; Pediatrics;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.259308

Filename

4461801