Title :
p53-Mdm2 core regulation revealed by a mathematical model
Author :
Yang, Yang ; Lin, Hai
Author_Institution :
Dept. of Electr. & Comput. Eng., Nat. Univ. of Singapore, Singapore
Abstract :
p53 is a paramount protein in cancer studies. p53-Mdm2 interaction is the core regulation for most activities of p53 protein-related networks. In this paper a new mathematical model is proposed to reveal the mechanisms existing in this core regulation. This model is mainly based on the recent biological findings, as well as few reasonable hypotheses and approximations. The performance is in good accord with the experimental phenomenon in the literature. And a new threshold mechanism is also discussed, which gives more insights for experimental design and validation.
Keywords :
cancer; cellular biophysics; molecular biophysics; proteins; tumours; DNA damage; cancer; cellular pathways; p53-Mdm2 core regulation; p53-Mdm2 interaction; protein; tumour suppressor; Amino acids; Bifurcation; Biological system modeling; DNA; Degradation; Ionizing radiation; Mathematical model; Protein engineering; Stress; Tumors; Bifurcation Analysis; Mathematical Model; Systems Biology; p53-Mdm2 Core Regulation;
Conference_Titel :
Systems, Man and Cybernetics, 2008. SMC 2008. IEEE International Conference on
Conference_Location :
Singapore
Print_ISBN :
978-1-4244-2383-5
Electronic_ISBN :
1062-922X
DOI :
10.1109/ICSMC.2008.4811537
