Title :
A low noise readout circuit for integrated electrochemical biosensor arrays
Author :
Zhang, Jichun ; Trombly, Nicholas ; Mason, Andrew
Author_Institution :
Dept. of Electr. & Comput. Eng., Michigan State Univ., East Lansing, MI, USA
Abstract :
This paper presents a low noise electrochemical interface circuit that is tuned to the needs of protein-based biosensor arrays and compatible with the formation of fully integrated biochemical microsystems. The circuit includes an integrated potentiostat and highly sensitive amperometric readout amplifier. It achieves good noise performance while supporting biosensor output currents from 10 pA to 10 μA to suit a wide range of sensitivities and electrode areas. Implemented in 0.5 μm CMOS process, it is compatible with a post-CMOS process to realize an integrated biosensor array.
Keywords :
CMOS integrated circuits; array signal processing; biosensors; electrochemical sensors; integrated circuit measurement; integrated circuit noise; potentiometers; proteins; readout electronics; 0.5 micron; 10 pA to 10 muA; CMOS process; amperometric readout amplifier; biosensor output currents; electrochemical interface circuit; electrode area; integrated biochemical microsystems; integrated electrochemical biosensor arrays; integrated potentiostat; low noise readout circuit; noise performance; post-CMOS process compatibility; protein-based biosensor arrays; sensitivity; Biosensors; CMOS process; Circuit noise; Current measurement; Electrodes; Proteins; Semiconductor device measurement; Sensor arrays; Switches; Voltage;
Conference_Titel :
Sensors, 2004. Proceedings of IEEE
Print_ISBN :
0-7803-8692-2
DOI :
10.1109/ICSENS.2004.1426093
