A low noise readout circuit for integrated electrochemical biosensor arrays

Author

Zhang, Jichun ; Trombly, Nicholas ; Mason, Andrew

Author_Institution

Dept. of Electr. & Comput. Eng., Michigan State Univ., East Lansing, MI, USA

fYear

2004

fDate

24-27 Oct. 2004

Firstpage

36

Abstract

This paper presents a low noise electrochemical interface circuit that is tuned to the needs of protein-based biosensor arrays and compatible with the formation of fully integrated biochemical microsystems. The circuit includes an integrated potentiostat and highly sensitive amperometric readout amplifier. It achieves good noise performance while supporting biosensor output currents from 10 pA to 10 μA to suit a wide range of sensitivities and electrode areas. Implemented in 0.5 μm CMOS process, it is compatible with a post-CMOS process to realize an integrated biosensor array.

Keywords

CMOS integrated circuits; array signal processing; biosensors; electrochemical sensors; integrated circuit measurement; integrated circuit noise; potentiometers; proteins; readout electronics; 0.5 micron; 10 pA to 10 muA; CMOS process; amperometric readout amplifier; biosensor output currents; electrochemical interface circuit; electrode area; integrated biochemical microsystems; integrated electrochemical biosensor arrays; integrated potentiostat; low noise readout circuit; noise performance; post-CMOS process compatibility; protein-based biosensor arrays; sensitivity; Biosensors; CMOS process; Circuit noise; Current measurement; Electrodes; Proteins; Semiconductor device measurement; Sensor arrays; Switches; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2004. Proceedings of IEEE

Print_ISBN

0-7803-8692-2

Type

conf

DOI

10.1109/ICSENS.2004.1426093

Filename

1426093