Dielectrophoretic cage-speed separation of bio-particles

Author

Medoro, G. ; Vulto, P. ; Altomare, L. ; Abonnenc, M. ; Romani, A. ; Tartagni, M. ; Guerrieri, R. ; Manaresi, N.

Author_Institution

Silicon Biosystems S.r.I., Bologna, Italy

fYear

2004

fDate

24-27 Oct. 2004

Firstpage

76

Abstract

A novel approach to the size characterization and separation of bio-particles is presented. Fluid-flow is not required to activate the separation since moving dielectrophoretic cages (MDC) (G. Medoro et al., IEDM, pp. 415-418, 2000) are used. By sequencing a set of cage patterns in a micro-fabricated chip, a movement can be induced or not on bio-particles depending on the ratio between the dielectrophoretic (DEP) mobility (H. Morgan and N.G. Green, Research Studies Press, 2003) and the cage-speed, causing selective particle transport. The effectiveness of the approach has been proven by experimental results with different sized beads. This approach can be easily combined with optical or impedance measurement for on-chip quantification of the mixture constituents for a miniaturized, automatic detection system.

Keywords

biosensors; electrophoresis; microfluidics; particle size measurement; AfDC; bio-particles; cage pattern sequencing; cage-speed; dielectrophoretic cage-speed separation; dielectrophoretic mobility; impedance measurement; induced bio-particle movement; lab-on-a-chip; micro-fabricated chip; miniaturized automatic detection system; mixture constituents; moving dielectrophoretic cages; on-chip quantification; optical measurement; selective particle transport; separation activation; size characterization; Biomedical optical imaging; Dielectrophoresis; Electrodes; Field-flow fractionation; Frequency; Permittivity; Protocols; Shape; Silicon; Surface resistance;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2004. Proceedings of IEEE

Print_ISBN

0-7803-8692-2

Type

conf

DOI

10.1109/ICSENS.2004.1426103

Filename

1426103