Title :
Mathematical model for the incorporation/release diffusion dynamics of solutes including therapeutic antibody
Author :
Giacomini, M. ; Bertone, S. ; Peragallo, I. ; Ruggiero, C.
Author_Institution :
Dip. of Informatics Syst. & Telematics, Univ. of Genova, Italy
Abstract :
In order to predict the incorporation/release diffusion dynamics of therapeutic antibody, a model of human IgG diffusion through nerve guidance channels is presented. With the aid of computer based simulation, it will help to simulate the incorporation/release diffusion dynamics of soluted, including therapeutic antibody, in engineered tissues, particularly fibronectin nerve guidance channels.
Keywords :
biodiffusion; digital simulation; neurophysiology; patient treatment; physiological models; proteins; computer based simulation; engineered tissues; fibronectin nerve guidance channels; human IgG diffusion; incorporation; mathematical model; release diffusion dynamics; solutes; therapeutic antibody; Biological materials; Computational modeling; Computer simulation; Degradation; Drugs; Humans; Injuries; Mathematical model; Nerve fibers; Surgery;
Conference_Titel :
Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on
Print_ISBN :
0-7803-7557-2
DOI :
10.1109/MCTE.2002.1175019
