Title :
Genomic signature: the mathematical functions associated with it
Author :
De Giacomo, N. ; de Santis, F.
Author_Institution :
Dept. of Informatica e Applicazioni R.M. Capocelli, Univ. of Salerno, Baronissi, Italy
Abstract :
Extensive data analyses support the proposal that each living organism possess a genomic signature consisting of oligonucleotide relative abundance values calculated from genomic sequences. The Chaos Game Representation shows that the core features characterizing the whole genome are preserved in short subsequences of it, validating the idea of a genomic signature. This paper present an alternative approach to the genomic signature detection. Although ensuring the same information retrieved from classical methods, it presents the advantage to be conceptually very simple and computationally less expensive.
Keywords :
chaos; genetics; interpolation; physiological models; polynomials; Chaos Game Representation; computationally less expensive; conceptually very simple; core features; genomic signature; living organism; mathematical functions; whole genome characterization; Bioinformatics; Chaos; DNA; Data analysis; Frequency estimation; Frequency measurement; Genetics; Genomics; Organisms; Sequences;
Conference_Titel :
Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on
Print_ISBN :
0-7803-7557-2
DOI :
10.1109/MCTE.2002.1175025