Title :
Microscopical characterization of nanocapsules templated on ionic crystals and biological cells towards bio-medical applications
Author :
Diaspro, A. ; Krol, S. ; Cavalleri, O. ; Silvano, D. ; Gliozzi, A.
Author_Institution :
Dept. of Phys., Genoa Univ., Genova, Italy
Abstract :
Nanocapsules represent a comparatively new class of colloids with controlled nanostructure. The use of crystals as core influences the wall texture and the properties of the capsules. Yeast cells constitute a candidate as core. They are a good system for testing the protective ability of shells and the permeability of the walls with respect to the needs of biological systems, namely: feeding and stability against attacks. The main features of the nanocapsules have been studied by two-photon, confocal and atomic force microscopy. Nanocapsules are of bio-medical interest since they can be used, for example, for the controlled release and targeting of drugs as well as for the protection of enzymes, proteins and foreign cells.
Keywords :
biomedical materials; cellular biophysics; colloids; crystals; drug delivery systems; nanostructured materials; permeability; polymer electrolytes; atomic force microscopy; biological cells; biomedical applications; capsules properties; confocal microscopy; controlled drug release; drugs targeting; enzymes protection; foreign cells; ionic crystals; microscopical characterization; proteins; two-photon microscopy; wall texture; yeast cells; Atomic force microscopy; Biological cells; Biological systems; Colloidal crystals; Fungi; Nanobioscience; Permeability; Protection; Stability; System testing;
Conference_Titel :
Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on
Print_ISBN :
0-7803-7557-2
DOI :
10.1109/MCTE.2002.1175047
