Title :
Wide dynamic range pulse modulation image sensor for on-chip bioimaging applications
Author :
Tokuda, Takashi ; Ng, David C. ; Okamoto, Hideki ; Kagawa, Keiichiro ; Ohta, Jun ; Nunoshita, Masahiro
Author_Institution :
Graduate Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Japan
Abstract :
Image sensors with a pulse modulation measurement scheme are fabricated for bioimaging and biosensing applications. We designed pulse modulation photosensors and a 64×64-pixel image sensor. We demonstrated the feasibility of the pulse modulation measurement scheme for biosensing applications. We obtained a dynamic range of 120 dB and minimum sensing intensity level of 2 nW/cm2. We also confirmed that 0.2% of intensity change is detectable at the minimum intensity region. An in-vitro, on-chip imaging of a mouse hippocampus was successfully demonstrated.
Keywords :
CMOS image sensors; biomedical optical imaging; biosensors; integrated circuit design; integrated optoelectronics; medical image processing; photodetectors; pulse modulation; 4096 pixel; 64 pixel; CMOS vision-chip-based image sensors; biosensing applications; dynamic range; minimum sensing intensity level; mouse hippocampus; on-chip bioimaging applications; pulse modulation image sensor; pulse modulation photosensors; Biosensors; CMOS image sensors; Dynamic range; Image sensors; Lighting; Pulse measurements; Pulse modulation; Pulse width modulation; Time measurement; Voltage;
Conference_Titel :
Sensors, 2004. Proceedings of IEEE
Print_ISBN :
0-7803-8692-2
DOI :
10.1109/ICSENS.2004.1426295
