Title :
Development of biodegradable PLGA microspheres for use as ultrasound contrast agents
Author :
El-Sherif, Dalia ; Wheatley, M.A.
Author_Institution :
Drexel Univ., Philadelphia, PA, USA
Abstract :
The authors have developed a method for producing hollow/porous poly (lactide co-glycolide) (PLGA) microcapsules with a mean size of 1 μm by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that make them useful as contrast agents for diagnostic imaging using ultrasound. Moreover, they are very stable and give a prolonged acoustic enhancement, as compared to other ultrasound contrast agents
Keywords :
biomedical materials; biomedical ultrasonics; evaporation; polymers; 1 mum; acoustic enhancements; biocompatible biodegradable microspheres; biodegradable PLGA microspheres; hollow porous poly (lactide co-glycolide) microcapsules; medical diagnostic imaging; modified double emulsion solvent evaporation technique; prolonged acoustic enhancement; ultrasound contrast agents; ultrasound imaging; Acoustic transducers; Biodegradable materials; Biological materials; Biomedical engineering; Chemical engineering; Polymers; Scanning electron microscopy; Solvents; Ultrasonic imaging; Ultrasonic variables measurement;
Conference_Titel :
Bioengineering Conference, 2001. Proceedings of the IEEE 27th Annual Northeast
Conference_Location :
Storrs, CT
Print_ISBN :
0-7803-6717-0
DOI :
10.1109/NEBC.2001.924712
