Use of lipid bilayers as support for biomolecules integration in OTFT biosensors

Author

Cotrone, S. ; Magliulo, M. ; Angione, M.D. ; Mallardi, A. ; Ambrico, M. ; Ligonzo, T. ; Colella, M. ; Palazzo, G. ; Torsi, L.

Author_Institution

Dipt di Chimica, Univ. of Bari, Bari, Italy

fYear

2010

fDate

4-7 July 2010

Firstpage

521

Lastpage

524

Abstract

Organic thin film transistor (OTFT) technology can be implemented to develop cost-effective and label-free bio-affinity sensor chips, having a field-effect transport directly coupled to a bio-sensing process, useful to high-throughput testing and point-of-care applications. Biological recognition elements such as antibodies or other proteins can be integrated in OTFT devices to confer specificity. In this study the use of lipid bilayers as support for biomolecules immobilization is investigated. Preliminary results in terms of electrical resistance and capacitance of the lipid bilayers are presented.

Keywords

biosensors; lipid bilayers; molecular biophysics; organic field effect transistors; proteins; thin film transistors; OTFT biosensors; antibodies; biological recognition elements; biomolecules; capacitance; cost-effective sensor chips; electrical resistance; field effect transport; high-throughput testing; label-free bioaffinity sensor chips; lipid bilayers; organic thin film transistor; point-of-care applications; proteins; Biosensors; Capacitance; Lipidomics; Organic semiconductors; Organic thin film transistors;

fLanguage

English

Publisher

ieee

Conference_Titel

Industrial Electronics (ISIE), 2010 IEEE International Symposium on

Conference_Location

Bari

Print_ISBN

978-1-4244-6390-9

Type

conf

DOI

10.1109/ISIE.2010.5637669

Filename

5637669