DocumentCode :
3125494
Title :
The Role of Mechanical Stimulation in Engineering of Extracellular Matrix (ECM)
Author :
Sebastine, Immanuel M. ; Williams, David J.
Author_Institution :
Wolfson Sch. of Mech. & Manuf. Eng., Loughborough Univ.
fYear :
2006
fDate :
Aug. 30 2006-Sept. 3 2006
Firstpage :
3648
Lastpage :
3651
Abstract :
The engineering of ECM in vitro is a critical area of research in tissue engineering. Cells respond to mechanical stimuli and regulate the metabolic functions via mechanotransduction and synthesise ECM. This paper reviews key pathways. In vitro studies of mechanotransduction on macroscopic tissues in specialised automated bioreactors that are capable of mimicking the physiological environment by applying different loads will help us to examine how mechanical loads influence intracellular signalling, subsequent behaviour of cells and the synthesis of ECM components
Keywords :
biological tissues; bioreactors; cellular biophysics; mechanoception; tissue engineering; ECM; automated bioreactor; extracellular matrix; intracellular signalling; macroscopic tissue; mechanical stimulation; mechanical stimuli; mechanotransduction; metabolic function; tissue engineering; Cities and towns; Electrochemical machining; Extracellular; Gene expression; In vitro; In vivo; Protein engineering; Signal processing; Signal synthesis; Tissue engineering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
ISSN :
1557-170X
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2006.260344
Filename :
4462588
Link To Document :
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