Title :
Optical Nanoprobes for Biosensing and Therapy
Author :
Philbert, Martin A. ; Xu, Hao ; Kopelman, Raoul
Author_Institution :
Michigan Univ., Ann Arbor, MI
Abstract :
The sol-gel based oxygen nanoprobe that provides for quantitative intracellular measurement of dissolved oxygen in living cells provides a compelling example of the use of these biologically-compatible nanoplatforms for noninvasive monitoring function in living cells. Photonic Explorers for Bioanalysis with Biologically Localized Embedding (PEBBLEs) are flexible polymer nanoplatforms that encapsulate sensing elements in a biocompatible format for quantitative measurement of intracellular ions or small molecules. These biosensors capitalize on micelle or condensation/hydrolysis techniques that allow for nanoscale fabrication of polyvinyl chloride, polydecyl methacrylate, polyacrylamide hydrogels, sol-gels or organically-modified silicates with controlled diameters in the range 20-250 nm
Keywords :
biological techniques; biomedical measurement; biosensors; cellular biophysics; nanotechnology; optical sensors; patient treatment; polymers; sol-gel processing; 20 to 250 nm; bioanalysis; biologically-compatible nanoplatforms; biosensor; condensation techniques; dissolved oxygen measurement; flexible polymer nanoplatforms; hydrolysis techniques; living cells; micelle; nanoscale fabrication; noninvasive monitoring function; optical nanoprobes; photonic explorers; quantitative intracellular measurement; sol-gel based oxygen nanoprobe; therapy; Biomedical optical imaging; Biosensors; Cells (biology); Fluorescence; Medical treatment; Nanobioscience; Nanoparticles; Neoplasms; Optical polymers; Optical sensors;
Conference_Titel :
Lasers and Electro-Optics Society, 2006. LEOS 2006. 19th Annual Meeting of the IEEE
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-9555-7
Electronic_ISBN :
0-7803-9555-7
DOI :
10.1109/LEOS.2006.279159
