DocumentCode
3128822
Title
Non-viral Charge Reversal Vectors for pDNA Delivery
Author
Prata, Carla A H ; Li, Yougen ; Luo, Dan ; McIntosh, Thomas J. ; Grinstaff, Mark W.
Author_Institution
Dept. of Biomed. Eng. & Chem., Boston Univ., MA
fYear
2006
fDate
Aug. 30 2006-Sept. 3 2006
Firstpage
4347
Lastpage
4349
Abstract
A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids
Keywords
DNA; bioelectric phenomena; cellular biophysics; genetics; molecular biophysics; anionic lipid; cationic lipid; charge-reversal lipid; cytotoxicity; electrostatic interactions; enhanced gene transfection; nonviral charge reversal vector; pDNA delivery; supramolecular complex; synthetic vector; Biomedical engineering; Chemistry; Cities and towns; DNA; Degradation; Design for experiments; Engineering in medicine and biology; Lipidomics; Temperature; USA Councils;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location
New York, NY
ISSN
1557-170X
Print_ISBN
1-4244-0032-5
Electronic_ISBN
1557-170X
Type
conf
DOI
10.1109/IEMBS.2006.260181
Filename
4462764
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