Biological evaluation of neoaspergillic acid, a pyrazine hydroxamic acid produced by mixed cultures of two marine-derived mangrove epiphytic fungi

Author

Wan, Xueqin ; Zhu, Feng ; Chen, Guangying ; Li, Hongming ; Tan, Shuyi ; Pan, Yanqiong ; Hong, Yin

Author_Institution

Med. Coll., Foshan Univ., Foshan, China

Volume

5

fYear

2010

fDate

16-18 Oct. 2010

Firstpage

1932

Lastpage

1935

Abstract

Neoaspergillic acid (NAA), a pyrazine hydroxamic acid, was produced by mixed cultures of two epiphytic fungi from a rotten fruit of mangrove Avicennia marina from the South China Sea. In the in vitro bioassays, NAA shows significant inhibitory activities against some Gram-positive and Gram-negative bacteria with MIC ranges of 0.49 - 15.62 μg/mL, and also exhibits moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562 with IC₅₀ ranges of 7.99 - 24.90 μg/mL.

Keywords

cellular biophysics; microorganisms; organic compounds; Avicennia marina; Gram-negative bacteria; Gram-positive bacteria; South China Sea; mangrove epiphytic fungi; neoaspergillic acid; pyrazine hydroxamic acid; Antibiotics; Cancer; Fungi; Microorganisms; Microwave integrated circuits; Nuclear magnetic resonance; Strain; Avicennia marina; antibacterial activity; cytotoxic activity; epiphytic fungus; mangrove; mixed culture; neoaspergillic acid;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on

Conference_Location

Yantai

Print_ISBN

978-1-4244-6495-1

Type

conf

DOI

10.1109/BMEI.2010.5639498

Filename

5639498