Title :
Biological evaluation of neoaspergillic acid, a pyrazine hydroxamic acid produced by mixed cultures of two marine-derived mangrove epiphytic fungi
Author :
Wan, Xueqin ; Zhu, Feng ; Chen, Guangying ; Li, Hongming ; Tan, Shuyi ; Pan, Yanqiong ; Hong, Yin
Author_Institution :
Med. Coll., Foshan Univ., Foshan, China
Abstract :
Neoaspergillic acid (NAA), a pyrazine hydroxamic acid, was produced by mixed cultures of two epiphytic fungi from a rotten fruit of mangrove Avicennia marina from the South China Sea. In the in vitro bioassays, NAA shows significant inhibitory activities against some Gram-positive and Gram-negative bacteria with MIC ranges of 0.49 - 15.62 μg/mL, and also exhibits moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562 with IC50 ranges of 7.99 - 24.90 μg/mL.
Keywords :
cellular biophysics; microorganisms; organic compounds; Avicennia marina; Gram-negative bacteria; Gram-positive bacteria; South China Sea; mangrove epiphytic fungi; neoaspergillic acid; pyrazine hydroxamic acid; Antibiotics; Cancer; Fungi; Microorganisms; Microwave integrated circuits; Nuclear magnetic resonance; Strain; Avicennia marina; antibacterial activity; cytotoxic activity; epiphytic fungus; mangrove; mixed culture; neoaspergillic acid;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on
Conference_Location :
Yantai
Print_ISBN :
978-1-4244-6495-1
DOI :
10.1109/BMEI.2010.5639498
