Modeling of Breast Cancer Cell Through Atomic Force Microscope

We study the biomechanical properties of MCF7 breast cancer cell based on an experimental measurement using atomic force microscopy (AFM). This paper consists of two parts. The first part corresponds to the experimental measurement of the force and displacement of the cell during probing through atomic force microscope. The second part which is the modeling part describes the mathematical relationship between nominal stress and nominal strain based on Neo-Hookean model. We found the material parameters of MCF7 cell in 3 experiments that C₁ are 2.12 x 10^-6 Pa, 2.72 x 10^-6 Pa and 2.31 x 10^-6 Pa and D₁ are 944.91 Pa, 736.08 Pa and 867.46 Pa respectively. Hence, we used these parameters and displacement to create a finite element model in ABAQUS. The model is capable of determining the forces-displacement and was then compared with the experiment data of force - indentation curve. The results of indentation force between AFM measurement and finite element model by ABAQUS are within the same range.