A mathematical model for acute hepatitis B virus infection

Based on the clinical data of acute hepatitis B patients and the HBV infection dynamic model proposed by Nowak et al., we construct a mathematical model to describe and understand the dynamics of host cells, virus and the immune system during the acute stages of the infection. Our model provide a possible interpretation for the phenomenon of acute hepatitis and acute-turn-chronic hepatitis. Based on our model, it can be shown that HBV can double as rapidly leading to the creation of viral loads that peak near 10⁹ HBV DNA copies, but HBV DNA rapid decline over several weeks. By numerical simulations, we can account for why patients show different symptom after acute hepatitis B virus infection.