PCA-based feature transformation for classification: issues in medical diagnostics

The goal of this paper is to propose, evaluate, and compare several data mining strategies that apply feature transformation for subsequent classification, and to consider their application to medical diagnostics. We (1) briefly consider the necessity of dimensionality reduction and discuss why feature transformation may work better than feature selection for some problems; (2) analyze experimentally whether extraction of new components and replacement of original features by them is better than storing the original features as well; (3) consider how important the use of class information is in the feature extraction process; and (4) discuss some interpretability issues regarding the extracted features.