Title :
A new injectable tissue engineered scaffold for regenerative medicine
Author :
Hosseinkhani, Hossein ; Hosseinkhani, Mohsen ; Kobayashi, Hisatoshi
Author_Institution :
Int. Center for Young Scientists, Nat. Inst. for Mater. Sci., Tsukuba
Abstract :
The failure of the application of tissue engineering in clinical trials is questionable. Tissue-engineering scaffolds used in tissue regeneration have micron structures that fail to be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure as a suitable surface structure for cell attachment, proliferation, and differentiation. In this study we designed an artificial ECM in order to mimic the nano-structured topography created by ECM components of native tissue. Selective differentiation of cardiomyocytes cells by self assembly of peptide-amphiphile nanofibers was studied for in vivo cardiac infarction therapy
Keywords :
biomedical materials; cardiovascular system; cellular biophysics; nanostructured materials; nanotechnology; self-assembly; surface structure; tissue engineering; artificial extracellular matrix; cardiomyocytes; cell attachment; cell differentiation; cell proliferation; chemical composition; in vivo cardiac infarction therapy; injectable tissue engineered scaffold; nano-structured topography; native extracellular matrix; peptide-amphiphile nanofibers; physical structure; regenerative medicine; self assembly; surface structure; tissue regeneration; Cardiology; Chemicals; Clinical trials; Electrochemical machining; Extracellular; In vivo; Regeneration engineering; Self-assembly; Surface structures; Tissue engineering; extracellular matrix; nanofibers; regeneration; scaffold; self-assembly;
Conference_Titel :
Microtechnologies in Medicine and Biology, 2006 International Conference on
Conference_Location :
Okinawa
Print_ISBN :
1-4244-0338-3
Electronic_ISBN :
1-4244-0338-3
DOI :
10.1109/MMB.2006.251477
