Title :
Semichronic, Collocated Deep Brain Stimulation and Multisite Recording in Rats
Author :
Gritsun, T. ; Litza, M. ; Hiller, A. ; Moser, A. ; Hofmann, Ulrich G.
Author_Institution :
Inst. for Signal Process., Univ. of Lubeck
Abstract :
Multisite microelectrode recording represents a suitable procedure to study microphysiology and network interactions in the central nervous system on a short time scale. This enables a deeper understanding of recent neurochemical studies to investigate changes in the neurotransmitter GABA caused by deep brain stimulation at the same position. We describe in the following a semichronic procedure to implant a miniature system bringing both stimulation and monitoring probes in close proximity in the caudate putamen of freely behaving rats. New multisite microelectrodes to replace existing microdialysis probes are built from spun wires, characterized and described. The design of a closed loop recording and stimulating system is discussed
Keywords :
biomedical electrodes; biomedical measurement; brain; microelectrodes; neurophysiology; patient treatment; GABA; central nervous system; deep brain stimulation; digital signal processor; microdialysis; microphysiology; microwires; multisite microelectrode recording; network interaction; neurochemical study; neurotransmitter; Brain stimulation; Central nervous system; Disk recording; Implants; Microelectrodes; Monitoring; Neurotransmitters; Probes; Rats; Wires; Deep Brain Stimulation; Digital Signal Processor; animal model; micro wires; microdialysis; multisite microelectrode;
Conference_Titel :
Microtechnologies in Medicine and Biology, 2006 International Conference on
Conference_Location :
Okinawa
Print_ISBN :
1-4244-0338-3
Electronic_ISBN :
1-4244-0338-3
DOI :
10.1109/MMB.2006.251497
