Title :
Development of Biosensor Chip for Clinical Diagnosis Using Surface Plasmon Resonance Imaging with Multi-Microchannels
Author :
Suzuki, T. ; Teramura, Y. ; Inokuma, K. ; Kanno, I. ; Iwata, H. ; Kotera, H.
Author_Institution :
Dept. of Microeng., Kyoto Univ.
Abstract :
A compact biosensor chip for clinical diagnosis is presented. The proposed biochip integrated three independent microchannels on one chip partially coated with Au thin film as a surface plasmon resonance (SPR) excitation layer. For clinical diagnosis, the affinity binding of unlabeled biological molecules onto the Au surface can be quantitatively analyzed by SPR imaging with the multi-microchannels, i.e. one biosample and two reference flows to obtain an analytical curve
Keywords :
biomedical optical imaging; biosensors; coatings; gold; lab-on-a-chip; microchannel flow; microsensors; molecular biophysics; proteins; surface plasmon resonance; Au; Au thin film coating; SPR excitation layer; affinity binding; analytical curve; biosensor chip; clinical diagnosis; miniaturized SPR sensors; multimicrochannels; protein adsorption; surface plasmon resonance imaging; unlabeled biological molecules; Biosensors; Bonding; Clinical diagnosis; Glass; Gold; Microchannel; Plasmons; Pollution measurement; Resonance; Substrates; Clinical Diagnosis; Multi-microchannels; Surface Plasmon Resonance Imaging;
Conference_Titel :
Microtechnologies in Medicine and Biology, 2006 International Conference on
Conference_Location :
Okinawa
Print_ISBN :
1-4244-0338-3
Electronic_ISBN :
1-4244-0338-3
DOI :
10.1109/MMB.2006.251505
