Title :
The NanoCytometer: Screening Cells Based on Cell Size
Author :
Carbonaro, A. ; Godley, L.A. ; Sohn, L.L.
Author_Institution :
Dept. of Mech. Eng., California Univ., Berkeley, CA
Abstract :
Determination of cell size is crucial in many biomedical applications. Here, we show how resistive-pulse sensing and artificial pores can be used to detect and measure cell size accurately. Cell size is determined by measuring the change in resistance when an individual cell passes through the pore. As a proof-of-principle, we show that we are able to measure the change in size when cells undergo apoptosis
Keywords :
bioMEMS; biomedical measurement; cell motility; microfluidics; particle size measurement; porosity; apoptosis; artificial pores; biomedical applications; cell screening; cell size determination; flow cytometry; microfluidic device; nanocytometer; resistance measurement; resistive-pulse sensing; Biomedical measurements; Current measurement; Electrical resistance measurement; Mechanical engineering; Microfluidics; Oncology; Particle measurements; Pressure measurement; Reservoirs; Size measurement; artificial pore; cell size; electronic sensing; flow cytometry;
Conference_Titel :
Microtechnologies in Medicine and Biology, 2006 International Conference on
Conference_Location :
Okinawa
Print_ISBN :
1-4244-0337-5
Electronic_ISBN :
1-4244-0338-3
DOI :
10.1109/MMB.2006.251529
