Title :
Microfluidic Devices for Ultra Wide Band Electromagnetic Spectroscopy of Single Cell
Author :
Akalin, T. ; Arscott, Steve ; Bocquet, Bertrand ; Bourzgui, N.E. ; Mille, V. ; Senez, Vincent ; Treizebre, Anthony
Author_Institution :
CNRS, Univ. of Lille, Villeneuve d´Ascq
Abstract :
By performing dielectric spectroscopy across a wide spectrum of frequencies (DC-THz), single-cell analysis could be performed without labeling process. That is why we are developing different micro structures, either planar/3D electrodes or transmission lines, and microfluidic devices using BIOMEMS technologies. In our devices, silicon or glass substrates are combined with polymeric materials and gold patterns. For low frequency (LF) applications, PDMS has been chosen while for high frequency (HF) structures, the PPTMDSO is preferred. We are designing the devices thanks to modeling and simulation using either COMSOL (LF) or CST (HF) softwares. Different designs have already been fabricated and are presented in this paper. Finally, we have performed single cell measurements for the low frequency range (<10 MHz) and the next step will focuse on high frequency measurements
Keywords :
bioMEMS; bioelectric phenomena; biological techniques; cellular biophysics; microfluidics; microsensors; polymers; submillimetre wave spectroscopy; 3D electrodes; BIOMEMS technologies; COMSOL software; CST software; dielectric spectroscopy; glass substrate; gold patterns; high frequency structures; low frequency applications; microfluidic devices; microimpedance sensor; microstructures; planar electrodes; polydimethylsiloxane; polymeric materials; silicon substrate; single cell measurements; single-cell analysis; transmission lines; ultra wide band electromagnetic spectroscopy; Dielectric substrates; Electrochemical impedance spectroscopy; Electrodes; Electromagnetic devices; Frequency measurement; Hafnium; Labeling; Microfluidics; Performance analysis; Ultra wideband technology; Electromagnetic Spectroscopy; Modeling; Planar Electrode; Single Cell; Transmission Line;
Conference_Titel :
Microtechnologies in Medicine and Biology, 2006 International Conference on
Conference_Location :
Okinawa
Print_ISBN :
1-4244-0338-3
Electronic_ISBN :
1-4244-0338-3
DOI :
10.1109/MMB.2006.251542