Peroxidative Damage Induced by Moderate White Noise Involved in Tau Hyperphosphorylation of Hippocampus in Mice

White noise makes peroxidative damage of the brain, dose it have effect on the phosphorylation of tau in hippocampus? We used 66 mice exposed to 80 dB SPL white noise for 3 days, 1 week, and 3 weeks respectively, then detected the changes of Superoxide dismulase (SOD) activity and malondialdehyde (MDA) content in inferior colliculus (IC), auditory cortex (AC), and hippocampus. Meanwhile we detected the levels of phosphorylation of microtubule-associated protein tau in hippocampus after 1 week and 3 weeks noise exposure. We found that compared with the control group, the value of SOD/MDA of the three brain regions especially the hippocampus of the noise group decreased significantly. At the same time the phosphporylation of tau increased obviously. Our results indicated that the moderate white noise exposure can induced peroxidative damage in IC, AC, and hippocampus; and the peroxidative damage may involved in tau hyperphosphorylation of hippocampus through the lemniscal path.