Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell

Author

Li, P.Y. ; Lai, P.S. ; Lin, C.C.

Author_Institution

Dept. of Chem., Nat. Chung Hsing Univ., Taichung, Taiwan

fYear

2009

fDate

2-4 Dec. 2009

Firstpage

1

Lastpage

5

Abstract

Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size ( < 200 nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.

Keywords

biological organs; biomedical materials; cancer; cellular biophysics; colloids; drugs; gynaecology; nanobiotechnology; particle size; polymer blends; surface morphology; breast MCF-7 cancer cells; breast cancer cell; cancer tissue; chemotherapy agents; copolymer; intracellular doxorubicin distribution; micellar encapsulation; multidrug resistance; particle size; poly(L-lactide)-vitamin E TPGS micelles; surface morphology; Biomembranes; Breast cancer; Cells (biology); Drug delivery; Encapsulation; Immune system; Nanobioscience; Polymers; Pumps; Surface resistance;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical and Pharmaceutical Engineering, 2009. ICBPE '09. International Conference on

Conference_Location

Singapore

Print_ISBN

978-1-4244-4763-3

Electronic_ISBN

978-1-4244-4764-0

Type

conf

DOI

10.1109/ICBPE.2009.5384064

Filename

5384064