DocumentCode
3160887
Title
Photosensitizing drugs loaded stable carrier-artificial oil bodies
Author
Chiou, Yu-Chi ; Lai, Ping-Shan
Author_Institution
Dept. of Chem., Nat. Chung-Hsing Univ., Taichung, Taiwan
fYear
2009
fDate
2-4 Dec. 2009
Firstpage
1
Lastpage
3
Abstract
The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.
Keywords
biomedical materials; cancer; drugs; oils; photochemistry; photodynamic therapy; F68 micelle; HeLa cells; carrier artificial oil bodies; nuclear localization; photosensitizing drugs; Chemicals; Constitution; Drugs; Encapsulation; Lubricating oils; Medical treatment; Microscopy; Petroleum; Technical Activities Guide -TAG; USA Councils;
fLanguage
English
Publisher
ieee
Conference_Titel
Biomedical and Pharmaceutical Engineering, 2009. ICBPE '09. International Conference on
Conference_Location
Singapore
Print_ISBN
978-1-4244-4763-3
Electronic_ISBN
978-1-4244-4764-0
Type
conf
DOI
10.1109/ICBPE.2009.5384067
Filename
5384067
Link To Document