Bovine-serum-albumin capped gold nanoparticles as bio-mimic system for the stereo-specified recognition of Dansyl-derivative amino acid

Recent activities of biochemistry as well as pharmaceutical research areas developed the use of Self-assembled Monolayer (SAM) technology to generate monomolecular films of biological molecules (e.g. proteins, enzymes, nucleic acids and carbohydrates) on various substrates. The formation of such monolayer systems is extremely versatile and can provide a method for the in-vitro development of bio-surfaces, which are able to mimic naturally occurring molecular recognition processes. A kind of bio-macromolecules named Bovine-Serum-Albumin (BSA), which is composed of asymmetric units (L-amino acids), is a versatile transporter protein. The primary function of BSA is carrying small molecules around the blood stream. In this work, the SAM of BSA on gold nanoparticles capped silica gel (5 /spl mu/m) and treated as chiral selector for enantiomeric recognition of Dansyl-derivative amino acid.