DocumentCode :
3179952
Title :
Capecitabine loaded polymeric micelles: Formulation, characterization and cytotoxicity study
Author :
Kuchekar, A.B. ; Pawar, A.P.
Author_Institution :
Poona Coll. of Pharmacy, Dept. of Pharmacetics, B.V.D.U., Pune, India
fYear :
2013
fDate :
24-26 July 2013
Firstpage :
412
Lastpage :
415
Abstract :
The aim of present study was to develop and characterize polymeric micelle (PMs) of anticancer drug, Capecitabine (CTB). Preliminary trial batches were employed to screen the significant formulation and process variables of CTB loaded polymeric micelles by Quality-by-Design (QbD) approach. Eight variables were screened and the results showed Eudragit S 100 and HP β Cyclodextrin (HP β-CD) to be the most significant factors influencing mean particle size and zeta potential of the polymeric micelle formulation. The main effects plot depicted that all the independent variables had a statistically significant effect on the response variables. The selected batch was then studied for different characterization parameters and for invitro cytotoxicity studies.
Keywords :
biomedical materials; cancer; cellular biophysics; drugs; electrokinetic effects; polymers; toxicology; Eudragit S 100; HP beta cyclodextrin; anticancer drug; capecitabine; invitro cytotoxicity study; polymeric micelle characterization; polymeric micelle formulation; quality-by-design approach; zeta potential; Drugs; Magnetic resonance imaging; Polymers; Anticancer; Capecitabine; Cytotoxicity; Polymeric micelles;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Advanced Nanomaterials and Emerging Engineering Technologies (ICANMEET), 2013 International Conference on
Conference_Location :
Chennai
Print_ISBN :
978-1-4799-1377-0
Type :
conf
DOI :
10.1109/ICANMEET.2013.6609332
Filename :
6609332
Link To Document :
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