Title :
Multicompartment retinal ganglion cells response to high frequency bi-phasic pulse train stimulation: Simulation results
Author :
Maturana, Matias I. ; Grayden, David B. ; Burkitt, Anthony N. ; Meffin, Hamish ; Kameneva, Tatiana
Author_Institution :
Dept. of Electr. Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia
Abstract :
Retinal ganglion cells (RGCs) are the sole output neurons of the retina that carry information about a visual scene to the brain. By stimulating RGCs with electrical stimulation, it is possible to elicit a sensation of light for people with macular degeneration or retinitis pigmentosa. To investigate the responses of RGCs to high frequency bi-phasic pulse train stimulation, we use previously constrained models of multi-compartment OFF RGCs. The morphologies of mouse RGCs are taken from the Chalupa set of the NeuroMorpho database. The cell models are divided into compartments representing the dendrites, soma and axon that vary between the cells. A total of 132 cells are simulated in the NEURON environment. Results show that the cell morphology plays an important role in the response characteristics of the cell to high frequency bi-phasic pulse train stimulation.
Keywords :
bioelectric phenomena; cellular biophysics; vision defects; visual evoked potentials; Chalupa set; NEURON environment simulation; NeuroMorpho database; RGC response; brain; electrical stimulation; high frequency biphasic pulse train stimulation; macular degeneration; multicompartment retinal ganglion cells; output neurons; retinitis pigmentosa; visual scene; Biological system modeling; Electrical stimulation; Mathematical model; Morphology; Nerve fibers; Retina;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6609439
