Title :
Normalized power variance change between pre-ictal and ictal phase of an epilepsy patient using NAT analysis: A case study
Author :
Aoki, Yuya ; Ishii, Ryo ; Iwase, Masami ; Ikeda, Shoji ; Hata, Masaharu ; Canuet, Leonides ; Imajo, Kaoru ; Tanaka, Mitsuru ; Matsuzaki, Hideaki ; Musha, Toshimitsu ; Takeda, Masanori
Author_Institution :
Dept. of Psychiatry, Osaka Univ., Suita, Japan
Abstract :
Variance of state variables shifts due to phase-instability and may serve as an early-warning signal of phase transition of complex systems such as an epileptic seizure of brain cortical activity. Neuronal Activity Topology (NAT) analysis calculates a normalized-power-variance (NPV) of electroencephalogram (EEG) data in each frequency band to obtain relative values comparable among different power states. In this study, using AT analysis, we investigated PV changes between the pre-ictal and ictal phase in a patient with mesial frontal lobe epilepsy. We also investigated interictal cortical electrical activity in each frequency band using exact low resolution brain electromagnetic tomography (eLORETA) analysis. AT analysis demonstrated a PV increase in beta frequency band at mesial frontal lobe in the pre-ictal period, and PV decrease in beta frequency band at mesial frontal lobe in ictal period. In addition, eLORETA analysis localized a beta band cortical electrical activity at mesial frontal lobe in the interictal period. These results indicate instability of cortical electrical activity at seizure onset zone in the pre-ictal phase and its stabilization by phase transition to ictal phase. Overall findings indicate that AT analysis can sensitively detect instability of cortical electrical activity and may serve as an early-warning signal of phase transition of cortical electrical activity.
Keywords :
bioelectric phenomena; electroencephalography; medical disorders; neurophysiology; EEG; NAT; NPV; beta band cortical electrical activity; beta frequency band; brain cortical activity; eLORETA; early-warning signal; electroencephalogram data; epilepsy patient; epileptic seizure; exact low resolution brain electromagnetic tomography analysis; ictal phase; interictal cortical electrical activity; mesial frontal lobe epilepsy; neuronal activity topology analysis; normalized power variance change; phase transition; phase-instability; preictal phase; seizure onset zone; Discharges (electric); Electrodes; Electroencephalography; Electromagnetics; Epilepsy; Magnetic resonance imaging; Tomography;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6609530