Title :
An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics
Author :
Tokuda, Takashi ; Nakajima, Shigeru ; Maezawa, Y. ; Noda, Toshio ; Sasagawa, Kiyotaka ; Ishikawa, Yozo ; Shiosaka, S. ; Ohta, Jun
Author_Institution :
Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Ikoma, Japan
Abstract :
A CMOS-based neural interface device equipped with an integrated micro light source array for optogenetics was fabricated and demonstrated. A GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor that is capable of on-chip current injection. We demonstrated a functionality of light stimulation onto ChR2-expressed cells in an in vitro experiment. A ChR2-expressed cell were successfully stimulated with the light emitted from the fabricated device.
Keywords :
CMOS image sensors; III-V semiconductors; biological techniques; biomolecular electronics; cellular biophysics; gallium compounds; genetics; indium compounds; light emitting diodes; molecular biophysics; neurophysiology; proteins; wide band gap semiconductors; Al2O3; CMOS-based optoelectronic neural interface device; ChR2-expressed cells; GaInN; GaInN LED array; in vitro demonstration; in vitro experiment; integrated microlight source array; light stimulation; multifunctional CMOS image sensor; on-chip current injection; optogenetics; sapphire substrate; Arrays; CMOS image sensors; CMOS integrated circuits; In vitro; Light emitting diodes; Performance evaluation; System-on-chip; Animals; Cell Line, Tumor; Electronics; Equipment Design; Ion Channel Gating; Light; Metals; Mice; Neurons; Optogenetics; Oxides; Rhodopsin; Semiconductors;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6609621
