A neuro-robotic system to investigate the computational properties of neuronal assemblies

Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. We used cultured networks coupled to MEAs (i.e. Micro Electrode Arrays) as a simplified model system to investigate the computational properties of neuronal assemblies. The proposed neuro-robotic framework provides a suitable experimental environment for embodied electrophysiology as it allows long-term multisite recording and stimulation in a closed-loop configuration. Here we present what the main components of the experimental system are and how they can be conveniently used to study coding mechanisms in neuronal systems.