Title :
Model-based measurement of gas exchange in healthy subjects using ALPE essential - influence of age, posture and gender
Author :
Karbing, Dan S. ; Thomsen, Lars P. ; Moesgaard, J. ; Andreassen, Steen ; Toft, Egon ; Thorgaard, Per ; Rees, Stephen E.
Author_Institution :
Aalborg Univ., Aalborg, Denmark
Abstract :
The ALPE Essential device for model-based measurement of pulmonary gas exchange status may be a useful alternative to current methods for diagnosing, monitoring and evaluating treatment related to pulmonary gas exchange. In this study, shunt and ventilation/perfusion mismatch were measured with ALPE Essential in 106 healthy subjects with the aim of investigating the influence of age, posture and gender on gas exchange parameters and evaluating the test-retest reliability of the measurements. Age and gender did not have statistically significant influence on gas exchange parameters, although there was a tendency for poorer matching of ventilation and perfusion with age. Posture was shown to be important when measuring gas exchange parameters. Absolute measurement reliability was acceptable with future studies in patients being necessary for accurate evaluation of relative reliability.
Keywords :
biomedical equipment; lung; patient diagnosis; patient monitoring; patient treatment; reliability; statistical analysis; ventilation; ALPE essential device; absolute measurement reliability; gas exchange parameters; healthy subjects; model-based measurement; patient diagnosis; patient monitoring; patient treatment; pulmonary gas exchange status; statistical significance; test-retest reliability; ventilation-perfusion mismatch; Blood; Correlation coefficient; Educational institutions; Lungs; Numerical models; Reliability; Ventilation;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610033
