Title :
Prioritization of candidate genes based on disease similarity and protein´s proximity in PPI networks
Author :
Ganegoda, Gamage Upeksha ; Jianxin Wang ; Fang-xiang Wu ; Min Li
Author_Institution :
Sch. of Inf. Sci. & Eng., Central South Univ., Changsha, China
Abstract :
Identifying the genes causing a genetic disease is a key challenge in human health. Recently molecular interaction data has been used to prioritize candidate genes with respect to a particular disease. As a result, different methods have been implemented to rank genes which cause a given disease. However it has been suggested in literature that, to prioritize candidate genes it is necessary to consider disease similarity along with the protein´s proximity to disease genes in a protein-protein interaction (PPI) network. This paper proposes a new algorithm called proximity disease similarity algorithm (ProSim) which considers both properties simultaneously. Prostate cancer, Alzheimer disease and diabetes mellitus type 2 case studies are then used to test the proposed method. Results in terms of leave-one-out cross validation and ROC curves indicate that the proposed approach outperforms existing methods.
Keywords :
cancer; genetics; molecular biophysics; proteins; Alzheimer disease; PPI networks; ProSim; ROC curves; candidate gene prioritization; diabetes mellitus-type 2; genetic disease; human health; leave-one-out cross validation; molecular interaction data; prostate cancer; protein proximity; protein-protein interaction network; proximity disease similarity algorithm; Alzheimer´s disease; Diabetes; Equations; Mathematical model; Prostate cancer; Proteins; disease similarity; prioritizing disease genes; protein proximity; protein-protein interaction network;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location :
Shanghai
DOI :
10.1109/BIBM.2013.6732471