Title :
A mathematical model of the dynamics for anti-HBV infection treatment with Peginterferon Alfa-2a
Author :
Min, Lequan ; Li, Weidong ; Su, Yongmei ; Kuang, Yang
Author_Institution :
Appl. Sci. Sch., Univ. of Sci. & Technol. Beijing, Beijing
Abstract :
Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.
Keywords :
DNA; differential equations; diseases; HBV DNA levels; HBeAg-positive chronic hepatitis B patients; Peginterferon Alfa-2a; antiHBV infection treatment; clinical data; differential equation systems; immune system; infected hepatocytes; DNA; Differential equations; Electronic mail; Immune system; Kinetic theory; Liver diseases; Mathematical model; Mathematics; Medical treatment; Statistics;
Conference_Titel :
Communications, Circuits and Systems, 2008. ICCCAS 2008. International Conference on
Conference_Location :
Fujian
Print_ISBN :
978-1-4244-2063-6
Electronic_ISBN :
978-1-4244-2064-3
DOI :
10.1109/ICCCAS.2008.4658004
