Title :
Parallel model of independent component analysis constrained by reference curves for HPLC-DAD and its solution by multi-areas genetic algorithm
Author :
Lizhi Cui ; Poon, Josiah ; Poon, Simon K. ; Kei Fan ; Hao Chen ; Kwan, Paul ; Junbin Coa ; Zhihao Ling
Author_Institution :
Sch. of Inf. Technol., Univ. of Sydney, Sydney, NSW, Australia
Abstract :
In order to separate a 3D chromatography, which is generated from High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD), into chromatograms and spectra, we proposed a model called parallel Independent Component Analysis constrained by Reference Curve (pICARC), which transforms the separation problem to a multi-parameter optimization issue. Then, A new algorithm named multi-areas Genetic Algorithm (mGA) is developed to search multiple solutions in parallel. It was demonstrated that our approach could successfully separate a given HPLC-DAD dataset into chromatograms and spectra with little errors and in short computational time.
Keywords :
biotechnology; chromatography; genetic algorithms; independent component analysis; 3D chromatography; HPLC-DAD; high performance liquid chromatography-diode array detector; multiareas genetic algorithm; multiparameter optimization; parallel independent component analysis; reference curves; separation problem; Biological cells; Compounds; Data models; Educational institutions; Genetic algorithms; Independent component analysis; Mathematical model; HPLC-DAD data set separation; mGA; pICARC;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location :
Shanghai
DOI :
10.1109/BIBM.2013.6732631
