Title :
Controller design for extracorporeal life support
Author :
Metz, S.I. ; Bartlett, Robert H. ; Jenkins, Janice M. ; Kabamba, Pierre T.
Author_Institution :
MRTHREE Inc., Ann Arbor, MI, USA
fDate :
31 Oct-3 Nov 1996
Abstract :
An automatic controller for extracorporeal life support (ECLS) was designed and tested in vivo. The design goal was to improve upon manually-operated ECLS by automatically adjusting system parameters to meet oxygen (O2) delivery and carbon dioxide (CO2) removal needs of the patient, while monitoring system performance to enhance safety. The patient/ECLS System was modeled by two first order systems with a time delay representing transit times for blood moving between the patient and blood gas sensors. One proportional-plus-integral controller adjusted blood flow based on venous O2 content, and another varied gas flow through the gas exchanger based on venous PCO2 measurements. Tuning of controllers was based on open loop step response. The controller was successfully implemented and validated in a sheep model. This controller would minimize the duration of support (thereby reducing cost and invasiveness of the procedure), as the patient would be weaned from support as cardiopulmonary function improved
Keywords :
artificial organs; biocontrol; controllers; CO2; CO2 removal; O2; O2 delivery; automatic controller design; blood gas sensors; cardiopulmonary function improvement; controllers tuning; extracorporeal life support; open loop step response; procedure cost; procedure invasiveness; proportional-plus-integral controller adjusted blood flow; safety enhancement; sheep model; support duration minimization; system parameters; system performance monitoring; venous O2 content; Automatic control; Automatic testing; Blood; Carbon dioxide; Computerized monitoring; Condition monitoring; In vivo; Life testing; Open loop systems; Patient monitoring;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.647636
