Title :
Model analysis of the interaction between perfusion pressure, MVO 2 and coronary flow control
Author :
Dankelman, J. ; Spaan, J.A.E.
Author_Institution :
Fac. of Mech. Eng. & Marine Technol., Delft Univ. of Technol., Netherlands
fDate :
31 Oct-3 Nov 1996
Abstract :
Changes in coronary perfusion pressure affect coronary arterial resistance (autoregulation) as well as myocardial oxygen consumption (Gregg´s phenomenon). The interaction between the effects of perfusion pressure and myocardial oxygen consumption on coronary flow control was investigated using a model. This model analysis predicts that autoregulation and Gregg´s phenomenon compete with each other in controlling coronary flow. The negative feedback system of the metabolic control system can become a positive feedback system when the level of arterial tone decreases and Gregg´s phenomenon becomes more important
Keywords :
cardiology; feedback; flow control; haemorheology; oxygen; physiological models; Gregg´s phenomenon; O2; arterial tone level; autoregulation; coronary flow control; metabolic control system; model analysis; myocardial oxygen consumption; negative feedback system; perfusion pressure; positive feedback system; Blood flow; Control systems; Electrical resistance measurement; Heart; Immune system; Marine technology; Mechanical variables measurement; Myocardium; Negative feedback; Pressure control;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.647643
