Title :
Construction and analysis of genetic regulatory boolean networks
Author :
Li-qin, Wang ; Yan, Li ; -zhi, Zhang Gui ; Jie, Yu
Author_Institution :
Dept. of Electr. Eng., Zhangjiakou Vocational Coll. of Technol., Zhangjiakou, China
Abstract :
In this paper, a new method to establish jointly the gene regulation network model based on the mutual information theory and the Boolean network will be proposed with examples and a logical rule has been derived as the expression value of one or multiple genes determined by multiple genes accordingly. Based on the logical rule, the gene electric network can be established and analyzed to realize the gene regulation network dynamic transformation, thus analyze the regulation relations among genes. This method can be used in the analysis and study of the biological gene regulatory networks, looking for differences between mutant gene networks changes and the normal gene dynamic changes to try to find the cause of the disease. This paper presents a new point of view that the gene network can be divided into two types as inhibitory and non-suppressed.
Keywords :
Boolean algebra; biology computing; diseases; genetics; information theory; biological gene regulatory networks; disease; gene electric network; gene regulation network dynamic transformation; gene regulation network model; genetic regulatory Boolean network analysis; genetic regulatory Boolean network construction; inhibitory type; logical rule; mutant gene networks changes; mutual information theory; nonsuppressed type; normal gene dynamic changes; Biology; Boolean logic function; Mutual information of entropy Boolean networks; gene regulatory networks;
Conference_Titel :
Information Technology in Medicine and Education (ITME), 2012 International Symposium on
Conference_Location :
Hokodate, Hokkaido
Print_ISBN :
978-1-4673-2109-9
DOI :
10.1109/ITiME.2012.6291442