DocumentCode
3198439
Title
Construction and analysis of genetic regulatory boolean networks
Author
Li-qin, Wang ; Yan, Li ; -zhi, Zhang Gui ; Jie, Yu
Author_Institution
Dept. of Electr. Eng., Zhangjiakou Vocational Coll. of Technol., Zhangjiakou, China
Volume
2
fYear
2012
fDate
3-5 Aug. 2012
Firstpage
873
Lastpage
876
Abstract
In this paper, a new method to establish jointly the gene regulation network model based on the mutual information theory and the Boolean network will be proposed with examples and a logical rule has been derived as the expression value of one or multiple genes determined by multiple genes accordingly. Based on the logical rule, the gene electric network can be established and analyzed to realize the gene regulation network dynamic transformation, thus analyze the regulation relations among genes. This method can be used in the analysis and study of the biological gene regulatory networks, looking for differences between mutant gene networks changes and the normal gene dynamic changes to try to find the cause of the disease. This paper presents a new point of view that the gene network can be divided into two types as inhibitory and non-suppressed.
Keywords
Boolean algebra; biology computing; diseases; genetics; information theory; biological gene regulatory networks; disease; gene electric network; gene regulation network dynamic transformation; gene regulation network model; genetic regulatory Boolean network analysis; genetic regulatory Boolean network construction; inhibitory type; logical rule; mutant gene networks changes; mutual information theory; nonsuppressed type; normal gene dynamic changes; Biology; Boolean logic function; Mutual information of entropy Boolean networks; gene regulatory networks;
fLanguage
English
Publisher
ieee
Conference_Titel
Information Technology in Medicine and Education (ITME), 2012 International Symposium on
Conference_Location
Hokodate, Hokkaido
Print_ISBN
978-1-4673-2109-9
Type
conf
DOI
10.1109/ITiME.2012.6291442
Filename
6291442
Link To Document