Title :
Network analysis reveals complex interactions in heat shock response in the malaria parasite
Author :
Lilburn, Timothy G. ; Hong Cai ; Jianying Gu ; Zhan Zhou ; Yufeng Wang
Author_Institution :
Dept. of Bacteriology, American Type Culture Collection, Manassas, VA, USA
Abstract :
Malaria is a serious infectious disease that affects 300-500 million people in the world. The proteins involved in heat shock response in the malaria parasite Plasmodium falciparum have long been considered as promising vaccine and drug targets. Our comprehensive network analysis reveals that about 103 heat shock proteins are associated with over 900 other proteins. They may play roles in a wide variety of cellular processes in parasite growth, development, and pathogenesis.
Keywords :
biochemistry; biothermics; cellular biophysics; data integration; diseases; drugs; medical computing; network analysis; proteins; cellular processes; complex interactions; comprehensive network analysis; drug targets; heat shock proteins; heat shock response; malaria parasite Plasmodium falciparum; parasite development; parasite growth; parasite pathogenesis; serious infectious disease; vaccine; Diseases; Drugs; Electric shock; Genomics; Heating; Proteins; Stress; data integration; heat shock; malaria; network; stress response; systems biology;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location :
Shanghai
DOI :
10.1109/BIBM.2013.6732711
