Network analysis reveals complex interactions in heat shock response in the malaria parasite

Author

Lilburn, Timothy G. ; Hong Cai ; Jianying Gu ; Zhan Zhou ; Yufeng Wang

Author_Institution

Dept. of Bacteriology, American Type Culture Collection, Manassas, VA, USA

fYear

2013

fDate

18-21 Dec. 2013

Firstpage

11

Lastpage

16

Abstract

Malaria is a serious infectious disease that affects 300-500 million people in the world. The proteins involved in heat shock response in the malaria parasite Plasmodium falciparum have long been considered as promising vaccine and drug targets. Our comprehensive network analysis reveals that about 103 heat shock proteins are associated with over 900 other proteins. They may play roles in a wide variety of cellular processes in parasite growth, development, and pathogenesis.

Keywords

biochemistry; biothermics; cellular biophysics; data integration; diseases; drugs; medical computing; network analysis; proteins; cellular processes; complex interactions; comprehensive network analysis; drug targets; heat shock proteins; heat shock response; malaria parasite Plasmodium falciparum; parasite development; parasite growth; parasite pathogenesis; serious infectious disease; vaccine; Diseases; Drugs; Electric shock; Genomics; Heating; Proteins; Stress; data integration; heat shock; malaria; network; stress response; systems biology;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on

Conference_Location

Shanghai

Type

conf

DOI

10.1109/BIBM.2013.6732711

Filename

6732711