DocumentCode :
3199819
Title :
Stability and bifurcation analysis of Hodgkin-Huxley model
Author :
Yue Zhang ; Kuanquan Wang ; Yongfeng Yuan ; Dong Sui ; Henggui Zhang
Author_Institution :
Biocomput. Res. Center, Harbin Inst. of Technol., Harbin, China
fYear :
2013
fDate :
18-21 Dec. 2013
Firstpage :
49
Lastpage :
54
Abstract :
Hodgkin-Huxley(HH) equation is a classical model in electrophysiology and has been studied by many scholars. Applying stability theory, and taking maximal sodium conductance g̅na and potassium conductance g̅k as variables, in this study we analyze the stability and bifurcations of the model. Bifurcations are found when the variables change, and bifurcation points and boundary are calculated. When g̅na is the variable, there is only one bifurcation point and there are two points when g̅k is variable. The (g̅na, g̅k) plane is partitioned into two regions and the upper bifurcation boundary is similar to a line when both g̅na and g̅k are variables. The results gotten could be a help to control relevant diseases caused by maximal conductance anomaly.
Keywords :
bifurcation; bioelectric phenomena; diseases; electrical conductivity; physiological models; potassium; sodium; Hodgkin-Huxley equation; Hodgkin-Huxley model; bifurcation analysis; bifurcation points; classical model; diseases; electrophysiology; maximal conductance anomaly; maximal sodium conductance; potassium conductance; stability analysis; stability theory; upper bifurcation boundary; variable change; Analytical models; Bifurcation; Eigenvalues and eigenfunctions; Mathematical model; Stability analysis; Thermal stability; HH; bifurcation; conductance; stability;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on
Conference_Location :
Shanghai
Type :
conf
DOI :
10.1109/BIBM.2013.6732717
Filename :
6732717
Link To Document :
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