Dynamic adjustments in DiFrancesco-Noble membrane kinetics during 2D reentrant propagation

Author

Papazoglou, Alexandra A. ; Henriquez, Craig S.

Author_Institution

Supercomput. Center, MCNC, Research Triangle Park, NC, USA

Volume

3

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

1248

Abstract

The DiFrancesco-Noble membrane model was used to investigate the spatio-temporal dynamics of spiral wave reentry. Two dimensional reentry was established in a 1 cm² region with elevated resistive properties without the onset of triggered waves or breakup. The time-course at sites near and far from the spiral core exhibited oscillations in magnitude, duration and diastolic take-off potentials with each cycle. The results suggest that due to their restitution characteristics, realistic membrane models may give rise to stable spiral reentry with small excitable gaps

Keywords

bioelectric phenomena; biomembrane transport; cardiology; physiological models; 2D reentrant propagation; DiFrancesco-Noble membrane kinetics; breakup; cardiac arrhythmias; cardiac electrophysiology; dynamic adjustments; elevated resistive properties; realistic membrane models; restitution characteristics; small excitable gaps; spatio-temporal dynamics; spiral core; spiral wave reentry; triggered waves; Analytical models; Anisotropic magnetoresistance; Biological system modeling; Biomedical engineering; Biomembranes; Cardiac tissue; Computer simulation; Kinetic theory; Partial differential equations; Spirals;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.652795

Filename

652795