Title :
Dynamic adjustments in DiFrancesco-Noble membrane kinetics during 2D reentrant propagation
Author :
Papazoglou, Alexandra A. ; Henriquez, Craig S.
Author_Institution :
Supercomput. Center, MCNC, Research Triangle Park, NC, USA
fDate :
31 Oct-3 Nov 1996
Abstract :
The DiFrancesco-Noble membrane model was used to investigate the spatio-temporal dynamics of spiral wave reentry. Two dimensional reentry was established in a 1 cm2 region with elevated resistive properties without the onset of triggered waves or breakup. The time-course at sites near and far from the spiral core exhibited oscillations in magnitude, duration and diastolic take-off potentials with each cycle. The results suggest that due to their restitution characteristics, realistic membrane models may give rise to stable spiral reentry with small excitable gaps
Keywords :
bioelectric phenomena; biomembrane transport; cardiology; physiological models; 2D reentrant propagation; DiFrancesco-Noble membrane kinetics; breakup; cardiac arrhythmias; cardiac electrophysiology; dynamic adjustments; elevated resistive properties; realistic membrane models; restitution characteristics; small excitable gaps; spatio-temporal dynamics; spiral core; spiral wave reentry; triggered waves; Analytical models; Anisotropic magnetoresistance; Biological system modeling; Biomedical engineering; Biomembranes; Cardiac tissue; Computer simulation; Kinetic theory; Partial differential equations; Spirals;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.652795
