Title :
A two-acoustic-waveguide-channel SH-APM urease biosensor
Author :
Liren, Wang ; Xue, Wu ; Sixin, Wang ; Xuesong, Ye ; Yuquan, Clicn
Author_Institution :
Dept. of Life Sci. & Med. Eng., Zhejiang Univ., Hangzhou, China
fDate :
31 Oct-3 Nov 1996
Abstract :
Designed with the finite element method (FEM) analysis, two pairs of interdigital transducers (IDT) were fabricated on the ZX-LiNbO3 substrate to form two SH-APM channels in the media. A mixture of polymer PVA (polyvinyl alcohol) and urease was used to form the bioreceptor film opposite to the IDT´s surface with an improved method in order to maintain the bioactivity of the enzyme and consequently enhance the detection accuracy. The concentration or urea was measured by detecting the frequency shift. Test results show that such bioreceptor film is stable and can be formed and polished easily and with little harm to the crystal surface
Keywords :
acoustic waveguides; biosensors; finite element analysis; interdigital transducers; proteins; LiNbO3; SH-APM channels; ZX-LiNbO3 substrate; bioactivity; bioreceptor film; crystal surface; detection accuracy; detection accuracy enhancement; finite element method analysis; polished film; polymer PVA; two-acoustic-waveguide-channel SH-APM urease biosensor; Acoustic sensors; Acoustic signal detection; Biochemistry; Biomedical measurements; Biosensors; Electric variables measurement; Equations; Mechanical variables measurement; Polymer films; Surface acoustic waves;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.656858
